Use Caution/Monitor. amiloride and oxaprozin both increase serum potassium. Use Caution/Monitor. WARNING: Nonsteroidal anti-inflammatory drugs (including oxaprozin) may rarely increase the risk of a heart attack or stroke. Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.Serious - Use Alternative (1)oxaprozin, trandolapril. atenolol and oxaprozin both increase serum potassium. oxaprozin, zanubrutinib. Use Caution/Monitor. Use Caution/Monitor. oxaprozin increases and nettle decreases anticoagulation. Monitor Closely (2)pivmecillinam, oxaprozin. Other (see comment). ketorolac will increase the level or effect of oxaprozin by acidic (anionic) drug competition for renal tubular clearance. Monitor Closely (2)oxaprozin and tolmetin both increase anticoagulation. oxaprozin, budesonide. For chronic conditions such as arthritis, continue taking it as directed by your doctor. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins. Use Caution/Monitor. pharmacodynamic antagonism. Make sure laboratory personnel and all your doctors know you use this drug. Minor/Significance Unknown. carvedilol and oxaprozin both increase serum potassium. Use Caution/Monitor.oxaprozin decreases effects of losartan by pharmacodynamic antagonism. Long term (>1 wk) NSAID use. Minor/Significance Unknown. Monitor Closely (1)eltrombopag increases levels of oxaprozin by decreasing metabolism. oxaprozin, ketorolac intranasal. If coadministration of an NSAID is necessary, closely monitor patients for toxicity, especially myelosuppression, renal toxicity, and GI toxicity. oxaprozin increases and metolazone decreases serum potassium. Caution is advised, both drugs have the potential to cause bleeding. Use Caution/Monitor. Effect of interaction is not clear, use caution. Minor/Significance Unknown. Use Caution/Monitor. Monitor Closely (3)candesartan, oxaprozin. Pain outcomes were standardized to a scale of 0 to 10, with effect size defined as small (0.5 to 1 point), moderate (more than 1 to 2 points), or large (more than 2 points). Monitor Closely (1)levofloxacin, oxaprozin. Use Caution/Monitor. pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. rivastigmine increases toxicity of oxaprozin by pharmacodynamic synergism. Monitor Closely (1)emtricitabine, oxaprozin. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals. Minor/Significance Unknown. Each drug may increase the photosensitizing effect of the other. Monitor Closely (2)oxaprozin and tolfenamic acid both increase anticoagulation. Do not double the dose to catch up. Minor/Significance Unknown. Use Caution/Monitor. oxaprozin increases and bendroflumethiazide decreases serum potassium. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. esmolol and oxaprozin both increase serum potassium. oxaprozin and parecoxib both increase serum potassium. Minor/Significance Unknown. NSAIDs decrease prostaglandin synthesis. Long term (>1 wk) NSAID use. Use Caution/Monitor. The Agency for Healthcare Research and Quality (AHRQ) review focused on seven common chronic pain conditions (neuropathic pain, fibromyalgia, osteoarthritis, inflammatory arthritis, low back pain, chronic headache, and sickle cell disease) and assessed the effectiveness of common nonopioid medications on the primary outcomes of pain, function, and quality of life, as well as adverse events related to these medications. Monitor Closely (1)antithrombin alfa and oxaprozin both increase anticoagulation. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.valsartan, oxaprozin. Comment: NSAIDs are known to increase bleeding. NSAIDs may delay pralatrexate clearance, increasing drug exposure. Use Caution/Monitor. Monitor Closely (1)oxaprozin increases and levalbuterol decreases serum potassium. benazepril, oxaprozin. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals. Use Caution/Monitor.Minor (1)oxaprozin increases levels of gentamicin by decreasing renal clearance. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API). spironolactone and oxaprozin both increase serum potassium. Clomipramine inhib. Either increases toxicity of the other by pharmacodynamic synergism. Either increases effects of the other by pharmacodynamic synergism. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. Use Caution/Monitor. aspirin and oxaprozin both increase anticoagulation. oxaprozin, benazepril. Use Caution/Monitor. The SNRI duloxetine resulted in moderate improvements in short-term pain and small improvements in short-term function and quality of life compared with placebo for people with diabetic peripheral neuropathy. Comment: Mechanism unknown. DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. Use Caution/Monitor. Use Caution/Monitor. oxaprozin increases and mistletoe decreases anticoagulation. Comment: Risk of CNS stimulation/seizure. NSAIDs decrease prostaglandin synthesis. Although low, there is systemic exposure to diclofenac topical; theoretically, concomitant administration with systemic NSAIDS or aspirin may result in increased NSAID adverse effects. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins. NSAIDs decrease prostaglandin synthesis. oxaprozin and parecoxib both increase anticoagulation. Modify Therapy/Monitor Closely. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.Serious - Use Alternative (1)oxaprozin, benazepril. NSAIDs decrease prostaglandin synthesis. Use Caution/Monitor. Modify Therapy/Monitor Closely. Therapeutic duplicationibuprofen and oxaprozin both increase anticoagulation. oxaprozin increases and norepinephrine decreases serum potassium. There are conflicting reports from studies of either increased or decreased IOP when ophthalmic prostaglandins are coadministered with NSAIDs (either systemic or ophthalmic). bisoprolol and oxaprozin both increase serum potassium. Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: fever, swollen lymph nodes, rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. Use Caution/Monitor. Use Caution/Monitor. Comment: Coadministration with medications that cause fluid and electrolyte abnormalities may increase the risk of adverse events of seizure, arrhythmias, and renal impairment. Use Caution/Monitor. Use Caution/Monitor. Effect of interaction is not clear, use caution. Serious - Use Alternative (1)aminolevulinic acid oral, oxaprozin. Either increases toxicity of the other by nephrotoxicity and/or ototoxicity. oxaprozin, betrixaban. NSAIDs decrease prostaglandin synthesis. moxifloxacin, oxaprozin. Les loyers peuvent tre trop levs pour esprer pouvoir se l'offrir seul (e). Use Caution/Monitor. oxaprozin increases and furosemide decreases serum potassium. Minor/Significance Unknown. bivalirudin and oxaprozin both increase anticoagulation. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals. . NSAIDs decrease prostaglandin synthesis. Toxicity may result from coadministration of emtricitabine with other drugs that are also primarily excreted by glomerular filtration and/or active tubular secretion including high-dose or multiple-dose NSAIDs; alternatives to NSAIDs should be considered. Minor (1)oxaprozin will increase the level or effect of valganciclovir by acidic (anionic) drug competition for renal tubular clearance. oxaprozin, alendronate. You should not use this medication after 30 weeks of pregnancy.It is unknown if this drug passes into breast milk. It is often used in arthritis. oxaprozin, captopril. Minor/Significance Unknown. Use Caution/Monitor. meloxicam and oxaprozin both increase anticoagulation. Use Caution/Monitor. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Some products that may interact with this drug include: aliskiren, ACE inhibitors (such as captopril, lisinopril), angiotensin II receptor blockers (such as losartan, valsartan), cidofovir, lithium, methotrexate, "water pills" (diuretics such as furosemide).This medication may increase the risk of bleeding when taken with other drugs that also may cause bleeding. oxaprozin increases levels of paromomycin by decreasing renal clearance. Monitor Closely (3)valsartan, oxaprozin. Use Caution/Monitor. Read More UGT inhibition; significance of interaction unclear. Minor (1)cefadroxil will increase the level or effect of oxaprozin by acidic (anionic) drug competition for renal tubular clearance. Most Monitor Closely (1)oxaprozin and garlic both increase anticoagulation. It was majorly used to treat joint pain due to Osteoarthritis and Rheumatoid Arthritis. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. sodium sulfate/?magnesium sulfate/potassium chloride increases toxicity of oxaprozin by Other (see comment). Use Caution/Monitor. Either increases toxicity of the other by Other (see comment). Increased risk of GI ulceration. Comment: Coadministration with medications that cause fluid and electrolyte abnormalities may increase the risk of adverse events of seizure, arrhythmias, and renal impairment. Avoid or Use Alternate Drug. OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. NSAIDs decrease prostaglandin synthesis. Effect of interaction is not clear, use caution. Avoid or Use Alternate Drug. oxaprozin increases and ethacrynic acid decreases serum potassium. unspecified interaction mechanism. Monitor Closely (1)fluoxetine, oxaprozin. The AHRQ review found that treatment with memantine resulted in moderate intermediate-term improvements in pain, function, and quality of life for fibromyalgia. (Theoretical interaction) Combination may have additive nephrotoxic effects. Use Caution/Monitor. Minor (1)oxaprozin increases levels of neomycin PO by decreasing renal clearance. serotonin uptake by platelets. Use Caution/Monitor. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis. Minor/Significance Unknown. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. Monitor Closely (1)benazepril, oxaprozin. cephalexin will increase the level or effect of oxaprozin by acidic (anionic) drug competition for renal tubular clearance. Avoid concurrent or sequential use to decrease risk for ototoxicity. Use Caution/Monitor. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. 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